Rhodanine derivatives as inhibitors of JSP-1

Neil S Cutshall; Christine O'Day; Marina Prezhdo

doi:10.1016/j.bmcl.2005.05.034

Rhodanine derivatives as inhibitors of JSP-1

Bioorg Med Chem Lett. 2005 Jul 15;15(14):3374-9. doi: 10.1016/j.bmcl.2005.05.034.

Authors

Neil S Cutshall¹, Christine O'Day, Marina Prezhdo

Affiliation

¹ Ceptyr Inc., 3830 Monte Villa Parkway, Suite 200, Bothell, WA 98021, USA. ncutshall@ceptyr.com

PMID: 15961311
DOI: 10.1016/j.bmcl.2005.05.034

Abstract

Dual-specificity phosphatases (DSPs) are a subclass within the protein tyrosine phosphatase family (PTPs). A series of rhodanine-based inhibitors was synthesized and shown to be novel, potent, and selective inhibitors against the DSP family member JNK-stimulating phosphatase-1 (JSP-1). Compounds of this class may be useful for the treatment of inflammatory and proliferative disorders.

MeSH terms

Drug Design
Dual-Specificity Phosphatases
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Mitogen-Activated Protein Kinase Phosphatases
Molecular Structure
Protein Phosphatase 1
Protein Tyrosine Phosphatases / antagonists & inhibitors*
Rhodanine / analogs & derivatives
Rhodanine / chemical synthesis
Rhodanine / pharmacology*
Structure-Activity Relationship

Substances

Enzyme Inhibitors
Rhodanine
Mitogen-Activated Protein Kinase Phosphatases
Protein Phosphatase 1
DUSP22 protein, human
Dual-Specificity Phosphatases
Protein Tyrosine Phosphatases